Transgenic Animals

/Tag:Transgenic Animals

Editorial: New Techniques for Producing Transgenic Animals

Coenraad Hendriksen and Horst Spielmann

New Techniques for Producing Transgenic Animals — a Mixed Blessing from Both the Scientific and Animal Welfare Perspectives. A further increase in the use of genetically-modified animals will be against the European Union policy to move away from the use of animals in biomedical research.
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Does the Use of Transgenic Animals Raise Particular Welfare and Ethical Concerns?

Michael Balls

There is a commonly held view that the protection of transgenic animals does not raise specific concerns and is adequately covered by existing controls on laboratory animal production and use, and that the transfer of genes among species, which is said to be a naturally occurring event in any case, does not involve any particular moral dilemmas. I do not share that opinion, nor did the authors of the ECVAM workshop report on The Use of Transgenic Animals in the European Union,1 which contained 39 conclusions and 14 recommendations, and is reproduced in full in this special issue of ATLA.
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2017-01-09T06:27:02+00:00 Tags: , |

The Use of Transgenic Animals in the European Union

T. Ben Mepham, Robert D. Combes, Michael Balls, Ottavia Barbieri, Harry J. Blokhuis, Patrizia Costa, Robert E. Crilly, Tjard de Cock Buning, Véronique C. Delpire, Michael J. O’Hare, Louis-Marie Houdebine, Coen F. van Kreijl, Miriam van der Meer, Christoph A. Reinhardt, Eckhard Wolf and Anne-Marie van Zeller

This is the report of the twenty-eighth of a series of workshops organised by the European Centre for the Validation of Alternative Methods (ECVAM). ECVAM’s main goal, as defined in 1993 by its Scientific Advisory Committee, is to promote the scientific and regulatory acceptance of alternative methods which are of importance to the biosciences and which reduce, refine or replace the use of laboratory animals.
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2017-01-09T06:27:02+00:00 Tags: |

Do Canadian Council on Animal Care Guidelines meet ECVAM Recommendations on Transgenic Animals?

Gilly Griffin and Clément Gauthier

The European Centre for the Validation of Alternative Methods (ECVAM) workshop report 28, on The Use of Transgenic Animals in the European Union (1), raises issues which need to be addressed in every country in which transgenic animals are used. While the systems of oversight of these animals vary among countries, since research and development crosses international boundaries, there must be recognition of the special considerations which need to be given to the creation and use of transgenic animals.
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2017-01-09T06:27:02+00:00 Tags: |

A Proposal for a New Ethical Scheme Addressing the Use of Laboratory Animals for Biomedical Purposes

Véronique C. Delpire, T. Ben Mepham and Michael Balls

Current European Union legislation relating to the use of laboratory animals, such as Directive 86/609/EEC, was implemented before the full implications of transgenesis were recognised. An analysis of selected existing cost-benefit guidelines has shown that they do not provide for an adequate evaluation of the use of transgenic animals. In this paper, a proposal is made for a new ethical scheme, comprising a specific cluster of questions dealing with transgenic animals and the wider implications of their use. It is suggested that this scheme could be used at the European level in reviewing project proposals involving animal experimentation.
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FRAME’s Response to an APC Questionnaire on Emerging Biotechnologies and The Animals (Scientific Procedures) Act 1986

Elizabeth S. Jenkins and Robert D. Combes

The Animal Procedures Committee (APC), chaired by The Reverend Professor Michael Banner, has recently reviewed the operation of the Animals (Scientific Procedures) Act 1986. This involved a consultation exercise, and a number of respondents raised concerns about new and emerging biotechnologies and, in particular, embryo manipulation, genetic modification and cloning.
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