personalised medicine

/Tag:personalised medicine

Artificial Human Tissues from Cord and Cord Blood Stem Cells for Multi-organ Regenerative Medicine: Viable Alternatives to Animal In Vitro Toxicology

Marcin Jurga, Nico Forraz and Colin P. McGuckin

New medicinal products and procedures must meet very strict safety criteria before being applied for use in humans. The laboratory procedures involved require the use of large numbers of animals each year. Furthermore, such investigations do not always give an accurate translation to the human setting.
Here, we propose a viable alternative to animal testing, which uses novel technology featuring human cord and cord blood stem cells. With over 130 million children born each year, cord and cord blood remains the most widely available alternative to the use of animals or cadaveric human tissues for in vitro toxicology.
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The Rational Use of Animals in Drug Development: Contribution of the Innovative Medicines Initiative

Magda Gunn, Elisabetta Vaudano and Michel Goldman

Animal models are still widely used to assess the efficacy or safety of new pharmaceutical products. Since their limitations in predicting actions of drugs in humans are becoming more and more apparent, there is an urgent need to revisit the use of animals in pharmaceutical research. Herein, we review how the Innovative Medicines Initiative (IMI), the largest public–private partnership in the life sciences, is reducing, refining and replacing the use of animals in the context of its global mission, namely, to boost research and the development of new medicines across the European Union.
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