Letters

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Letters

<h3>Alim Louis Benabid, Mahlon Delong & Marwan Hariz

Jarrod Bailey</h3>

Letters re: Bailey, J. (2014). Monkey-based research on human disease: The implications of genetic differences. ATLA 42, 287–317.
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Letter

Iain F H Purchase & Maria Nedeva

We are encouraged by the Editorial by Michael Balls,1 commenting on our paper, The impact of the Ethical Review Process for research using animals in the UK: attitudes to alternatives among those working with experimental animals.2 Some of the findings do indeed reveal some surprising answers.
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Letters to the Editor

Sebastian Hoffmann, Thomas Hartung and Jan Beran

Worth & Cronin have addressed the important question of how to compare and judge the predictive abilities of different two-group classification models (1). Such data are usually shown as 2 × 2 contingency tables, where test results (such as ositive/negative, toxic/non-toxic) are subdivided according to a reference method or gold standard. The contingency table permits the deduction of some descriptions such as sensitivity, specificity and accuracy, termed "Cooper statistics" - in the article. The authors ndertook to apply "bootstrap resampling" in order to estimate confidence intervals for these descriptors, by using the database of four skin corrosivity tests for illustration. Some inconsistencies in the application of bootstrap resampling to "Cooper statistics" prompted a critical review of the whole proposed method.
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Letter to the Editor

Chris Bowers

For many years, I have admired the stance taken by the Fund for the Replacement of Animals in Medical Experiments (FRAME) in working with the scientific community in attempting to replace animals used in medical experiments. But with the extremist positions of, on the one hand, the animal rights fanatics and, on the other, the diehard members of the scientific community seemingly getting more polarised, I feel there is a need for FRAME to adopt a more high-profile approach to its work.
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Letters

Stuart W.G, Chris Langley, Andrew Knight, Katy Taylor, Nicky Gordon, Gill Langley and Wendy Higgins

Animal and Human Pain
Animal Pain Research is Scientifically Valid: Whether it is Morally Acceptable is a Separate Question
Better Models of Human Pain
Estimates of Worldwide Laboratory Animal Use
127 Million Non-human Vertebrates Used Worldwide for Scientific Purposes in 2005
Estimates for Worldwide Laboratory Animal Use in 2005: Authors’ Response
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Letters

Andrew Knight, André Menache

Animal Models: Inefficient in Advancing Human Healthcare
Time to “Raise the Bar” in Fundamental Research Which Involves the Use of Animals
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Letter

Kristie Sullivan, Erin Hill

We invite your readers to support a new scientific society dedicated to the advancement of in vitro, in silico, and other toxicological testing methods, especially as replacements for animal-based tests. The American Society for Cellular and Comp - utational Toxicology (ASCCT) aims to build on the success of similar societies outside the Americas and the growing interest in advancing toxicology for practical, scientific, and ethical reasons.
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