ECVAM

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The Björn Ekwall Memorial Award 2015

Introduction by Ada Kolman & lecture text by Michael Balls

A personal, and therefore unavoidably biased, review is given, of the significance of the contributions made by selected Scandinavian individuals, organisations and events, to the development of in vitro toxicology procedures as potential replacements for toxicity tests in laboratory animals. In addition to their wider significance, these contributions had a profound effect on whatever contributions I have been able to make, myself. Nevertheless, while there has been much progress in the last 35 years or so, and many lessons have been learned, there is still much to be done, especially as animal tests remain entrenched as the preferred methods which set the gold standards and make regulators feel comfortable. Many of the clues to dealing with the questions and concerns which plague hazard prediction and risk assessment have long been available, but they have been ignored, largely for reasons which have little to do with the science of toxicology and the need to maintain the highest scientific standards. I have little doubt that Björn Ekwall, whose memory I feel privileged to honour, would have agreed with that last statement.
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Progress Toward the Validation of Alternative Tests

Michael Balls and Julia H. Fentem

ECVAM's role in the practical validation of replacement alternative methods for use in regulatory testing is reviewed, including an outline of the criteria which have been used in determining ECVAM's priorities. Some of the difficulties which have arisen in validation studies are discussed, and solutions to these are proposed, with particular emphasis on ensuring that methods are sufficiently well-developed to enter the validation process, and on the ECVAM prevalidation scheme for encouraging protocol optimisation and the prior assessment of interlaboratory transferability. Comments are made on problems encountered in selecting test materials backed by adequate in vivo data and in undertaking appropriate in vivo/in vitro comparisons.
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Current Status and Future Developments of Databases on Alternative Methods

Annett Janusch, Margot D.O. van der Kamp, Krys Bottrill, Barbara Grune, David C. Anderson, Björn Ekwall, Michelle Howald, Roman Kolar, Hans J.D. Kuiper, Jean Larson, Gregorio Loprieno, Ursula G. Sauer, Adrian J. Smith and Jan B.F. van der Valk

This is the report of the twenty-fifth of a series of workshops organised by the European Centre for the Validation of Alternative Methods (ECVAM). ECVAM’s main goal, as defined in 1993 by its Scientific Advisory Committee, is to promote the scientific and regulatory acceptance of alternative methods which are of importance to the biosciences and which reduce, refine or replace the use of laboratory animals.
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2017-01-09T06:26:22+00:00 Tags: , , |

ECVAM News & Views

ATLA Staff Writer

Call for Laboratories to Participate in the Formal Validation of Three In Vitro Embryotoxicity Tests
The ECVAM International Validation Study on In Vitro Tests for Skin Corrosivity: Statement on the Outcome of the Validation Study by the Management Team and Sponsors
Eye Irritancy Initiatives
A Meeting of Representatives of European National Centres (or Equivalent) on Alternatives
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2017-01-09T06:26:23+00:00 Tags: |

Genetically Engineered Cell Lines: Characterisation and Applications in Toxicity Testing

Friedrich J. Wiebel, Tommy B. Andersson, Daniel A. Casciano, Maurice Dickins, Volker Fischer, Hansruedi Glatt, Jean Horbach, Robert J. Langenbach, Walter Luyten, Gino Turchi and Alain Vandewalle

This is the report of the twenty-sixth of a series of workshops organised by the European Centre for the Validation of Alternative Methods (ECVAM). ECVAM’s main goal, as defined in 1993 by its Scientific Advisory Committee, is to promote the scientific and regulatory acceptance of alternative methods which are of importance to the biosciences and which reduce, refine or replace the use of laboratory animals.
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2017-01-09T06:26:27+00:00 Tags: , , |

Issues Relating to the Release of Proprietary Information and Data for Use in the Validation of Alternative Methods

Martin Todd, Bernward Garthoff, Wilfried Bernhardt, Gerd Bodé, Spencer Farr, Roman Kolar, Cyndy Lumley, Moniek Pieters, Vera Rogiers, Ursula Sauer, Horst Spielmann, Joseph Straus and Lars Warngard

This is the report of the twenty-seventh of a series of workshops organised by the European Centre for the Validation of Alternative Methods (ECVAM). ECVAM’s main goal, as defined in 1993 by its Scientific Advisory Committee, is to promote the scientific and regulatory acceptance of alternative methods which are of importance to the biosciences and which reduce, refine or replace the use of laboratory animals.
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2017-01-09T06:26:28+00:00 Tags: , , |

The Use of Transgenic Animals in the European Union

T. Ben Mepham, Robert D. Combes, Michael Balls, Ottavia Barbieri, Harry J. Blokhuis, Patrizia Costa, Robert E. Crilly, Tjard de Cock Buning, Véronique C. Delpire, Michael J. O’Hare, Louis-Marie Houdebine, Coen F. van Kreijl, Miriam van der Meer, Christoph A. Reinhardt, Eckhard Wolf and Anne-Marie van Zeller

This is the report of the twenty-eighth of a series of workshops organised by the European Centre for the Validation of Alternative Methods (ECVAM). ECVAM’s main goal, as defined in 1993 by its Scientific Advisory Committee, is to promote the scientific and regulatory acceptance of alternative methods which are of importance to the biosciences and which reduce, refine or replace the use of laboratory animals.
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2017-01-09T06:26:28+00:00 Tags: , , |

Reducing the Use of Laboratory Animals in Biomedical Research: Problems and Possible Solutions

Michael F.W. Festing, Vera Baumans, Robert D. Combes, Marlies Halder, Coenraad F.M. Hendriksen, Bryan R. Howard, David P. Lovell, Graham J. Moore, Philip Overend and Marie S. Wilson

This is the report of the twenty-ninth of a series of workshops organised by the European Centre for the Validation of Alternative Methods (ECVAM). ECVAM’s main goal, as defined in 1993 by its Scientific Advisory Committee, is to promote the scientific and regulatory acceptance of alternative methods which are of importance to the biosciences and which reduce, refine or replace the use of laboratory animals. One of the first priorities set by ECVAM was the implementation of procedures which would enable it to become well-informed about the state-of-the-art of non-animal test development and validation, and the potential for the possible incorporation of alternative tests into regulatory procedures.
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2017-01-09T06:26:42+00:00 Tags: , , |