An Assessment of Progress in the Use of Alternatives in Toxicity Testing since the Publication of the Report of the Second FRAME Toxicity Committee (1991)
Robert Combes, Michael Balls, Lee Bansil, Martin Barratt, David Bell, Phil Botham, Caren Broadhead, Richard Clothier, Elizabeth George, Julia Fentem, Michael Jackson, Ian Indans, Georg Loizou, Vyra Navaratnam, Victor Pentreath, Barry Phillips, Henry Stemplewski and Jane Stewart
The first FRAME Toxicity Committee was formed in October 1979, with the following remit: a) to conduct a thorough review of current toxicity testing procedures, to assess their reliability and suitability, and to make recommendations for their modification; b) to assess the prospects for developing in vitro, target organ and theoretical model systems which would lead to a reduction in studies on live animals; and c) to act as an advisory group to a FRAME Research Fund for the support of projects aimed at the development and validation of alternative methods for use in toxicity testing.
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