Estimation of the Toxicity of Silver Nanoparticles by Using Planarian Flatworms

///Estimation of the Toxicity of Silver Nanoparticles by Using Planarian Flatworms

Estimation of the Toxicity of Silver Nanoparticles by Using Planarian Flatworms

Leonid Kustov, Kharlampii Tiras, Souhail Al-Abed, Natalia Golovina and Mikhail
Ananyan

The regeneration of planarian flatworms — specifically, changes to the area of the regeneration bud (blastema) after surgical dissection — was proposed for use as a robust tool for estimating the toxicity of silver nanoparticles. The use of Planaria species, due to their unique regenerative capacity, could  result in a reduction in the use of more-traditional laboratory animals for toxicity testing. With our novel approach, silver nanoparticles were found to be moderately toxic to the planarian, Girardia tigrina.
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