Andrew P. Worth and Julia H. Fentem

A stepwise (hierarchical) testing strategy is an approach to hazard evaluation based on the sequential application of one or more alternative methods prior to the use of any animal tests which are considered necessary. The purpose of a stepwise testing strategy is to reduce and refine the use of animals in toxicity testing without compromising human safety.
You need to register (for free) to download this article. Please log in/register here.